bolognese

Early Clinical Development Planning via Biomarkers, Clinical Endpoints, and Simulation: A Case Study to Optimize for Phase 3 Dose Selection

Evaluation of an Adaptive Maximizing Design Study Based on Clinical Utility Versus Morphine for TRV130 Proof-of-Concept and Dose-Regimen Finding in Patients With Postoperative Pain After Bunionectomy

An Intra-Articular, Extended-Release Formulation of Triamcinolone Acetonide Prolongs and Amplifies Analgesic Effect in Patients With Osteoarthritis of the Knee: a Randomized Clinical Trial

Impact of Phase 2b Strategies on Optimization of Drug Development Programs

Methodological Extensions of Phase 2 Trial Designs Based on Program-level Considerations: Further Development of a Case Study in Neuropathic Pain

A Randomized, Phase 2 Study Investigating TRV130, a Biased Ligand of the μ-opioid Receptor, for the Intravenous Treatment of Acute Pain