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pain
Research Designs for Proof-of-Concept Chronic Pain Clinical Trials: IMMPACT Recommendations
Evaluation of an Adaptive Maximizing Design Study Based on Clinical Utility Versus Morphine for TRV130 Proof-of-Concept and Dose-Regimen Finding in Patients With Postoperative Pain After Bunionectomy
Methodological Extensions of Phase 2 Trial Designs Based on Program-level Considerations: Further Development of a Case Study in Neuropathic Pain
A Randomized, Phase 2 Study Investigating TRV130, a Biased Ligand of the μ-opioid Receptor, for the Intravenous Treatment of Acute Pain